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Laminine Studies (YTE Studies)

This article shows the Summary only of YTE Young Tissue Extract Clinical Studies. There are full versions of Laminine Clinical Studies but they are exclusive property of LifePharm Global Network. 


The avian egg is an important source of nutrients, containing all the proteins, lipids, vitamins, minerals and growth factors required by the developing embryo, as well as a number of defense factors to protect against bacterial and viral infections. Moreover, eggs are now understood to contain substances with biological functions beyond basic nutrition, and extensive research has been undertaken to identify and characterize these biologically active components (Kovacs-Nolan J, Philips M, Mine Y: Advances in the value of eggs and egg components for human health. J. Agra Food Chem. 2005; 53:8421-31)

YTE™ is a patented extract from fertilized, partially incubated hen eggs, obtained through separation of oligopeptides from the total mass. These have molecular weights of 0.5 – 1.8 kD and are able to pass freely through the digestive barrier. These embryonic peptides work via elevation of 17-ketosteroid levels in the adrenal glands which improve anabolism through increased synthesis of androgens and a decrease in the catabolic hormone cortisol, which offers multiple benefits. Initially, a less processed powder using the whole content of the egg (excluding shell) was used. Administration was in powder form in sachets. The taste of the product was not considered as acceptable to the public. Later (from 1999) separation of inactive parts were performed before further processing, hence providing a more concentrated powder. This was first planned for use in tablets, but putting it in tablet form proved difficult due to hygroscopic properties.

The present product in hard-gel capsules has been on the market since 2001. The difference between the original powder (as used in clinical work prior to 1999) and the second generation product equates to 1:1.79, i.e. that 1.79 g of old product corresponds to 1 g of the currently available YTE™.

Initial trials with the original product were of experimental character and have not been reported. These gave, however, grounds for expectations of libido enhancing properties, improvement of stamina and muscle strength, mood enhancement and also other properties. The first structured studies were performed during 1992 (ref 1) in order to investigate the effects on sexual desire with a follow-up during 1992/93 (ref 2) with the same purpose. Both of these studies were double-blind, placebo-controlled studies. These two studies were published in an article in the Journal of International Medical Research in 1997 (ref 4) together with the conclusions of an open post-marketing study performed in Sweden (ref. 3). This last study supports the findings of the two placebo controlled studies, but cannot be used as documentation alone.

As it is known that antidepressant medication often leads to decreased sexual lust and performance, a small pilot-study in patients on antidepressant medication (SRI) for a minimum of 6 weeks were performed in Denver, Colorado during 1996/97. Although a small sample size, this study gave statistically significant results. (Ref 5) At the same time an animal study was performed in Japan in order to study the effects on sexual behavior of YTE™ in rats. The results of this study is consistent with the findings in the human studies – further documenting the findings that YTE™ has a stimulating effect on the sexual desire and behavior.(ref. Pre-clinical 1)

In order to study the effects on physical performance, muscle size etc a study was performed during the same period – also in Denver, Colorado. As creatine is widely used among body builders, this substance was used as placebo treatment, while a combination of YTE™ and creatine was used as active treatment. As the effects of creatine are known, this study can be regarded as a test against creatine (as placebo) and no treatment (given the documented effects of creatine). The result of this showed that the addition of YTE™ gave a significant increase in motivation (mental effect) as well as a non-significant improvement in strength and muscle size. On this basis we can conclude that YTE™ has a tendency to increase the effects of creatine in bodybuilding, i.e. a positive effect in strength and muscle size. (Ref. 6) A hypothesis was during this period established that the clinical effects seen were due to hormonal effects. A study into the hormonal effects was subsequently performed in Oslo, Norway, into the hormonal effects of a single dose of YTE™.

This study was designed solely with the aim of testing potential hormonal changes as a result of a large, single dose of YTE™ and showed that YTE™ may significantly reduce cortisol levels and improve the cellular uptake of testosterone – thus supporting the hypothesis that these hormonal effects may help explain the clinical effects seen. (Ref. 7) Another study was performed during the same period on 14 elite soldiers of the Norwegian Armed Forces into muscular strength, restitution time and quality of life, but the details of this study are missing. (At the time, Med-Eq was only partially involved in the process.) Further studies Med-Eq has sponsored two studies into the mood enhancing properties of YTE™. These studies use the present recommended dosage of four YTE capsules per day of 420 mg each. The results of these studies have been submitted for publication and are also attached in this document. Several studies have also been performed into the effects in memory enhancement, and the results of these studies are under processing with the intention of submitting for publications. Conclusions

The two studies on YTE for stress and anti depressant concluded that YTE selectively improves adaptation to acute stress by normalizing the endocrine and the subjective stress response and that YTE might have a place in the treatment of mood disorders as a supplement to drug treatments used today.
It can also be stated that YTE™ strengthens the effect of creatine and this may be of value to people exercising and building muscles. (The Norwegian Army study also indicated that YTE™ alone gave improvements in muscle strength and restitution time.) The Academy of Sports study shows that YTE™ has an effect on the cortisol levels in the blood and the cellular uptake of testosterone. Clinical and animal studies provide sufficient documentation that YTE™ has a stimulatory effect on sexual lust and behavior – in the population in general as well as in patients experiencing lack of sexual lust due to antidepressant medication.

Clinical Studies Summary


Effects of powdered fertilized eggs on the stress response Background: Effects of nutritional supplements on psychological wellbeing receive increasing attention. This double-blind placebo-controlled study investigated effects of a four week intake of powder of fertilized eggs (YTE) in a laboratory protocol (Trier Social Stress Test; TSST). Methods: Aside the laboratory stress test, we examined differential effects on subjects with high and low levels of chronic stress. Thus, subjects were further divided into two subgroups with scores for chronic stress scores below and above average, respectively. Results: Beneficial effects of YTE were observed in subjects with enhanced levels of chronic stress. When compared to placebo these subjects showed an improvement of both the psychological and endocrine stress response.

Conclusions: Group differences suggest that YTE selectively improves adaptation to acute stress by normalizing the endocrine and the subjective stress response. Subjects with less chronic stress also reported less subjective stress but did not show beneficial effects on the endocrine stress response.


A placebo controlled, double-blind study on the efficacy of a nutritive supplement containing embryonic peptides in treatment of mild to moderate depressive mood. Background: Embryonic oligopeptides might have a therapeutic effect in the treatment of depressed mood. Objectives: To investigate if a powder from fertilized eggs have a clinical effect on patients with mild to moderate depressed mood Methods: In the present comparative, randomized, placebo controlled, double–blind, parallel group study we have investigated the effect of a nutritive supplement containing embryonic peptides (YTE™) in the treatment of mood disorders. Patients with mild to moderate mood disorders according to Hamilton rating scale (Ham-D) and Beck Depression Inventory (BDI) were included in the study according to the protocol. The patients were randomly assigned to receive placebo, Deprevent™ (YTE) or Deprevent™ Forte (YTE plus lemon balm extract) for 12 weeks. The main outcome was change in the Ham-D total score from baseline to 12 weeks as well change in BDI from baseline to controls after 3, 6 and 12 weeks.

Results: 57 patients concluded the study. It was a significant effect in favor of the two active groups in the primary outcome measures as compared to placebo. Between the two active groups, however, there was no significant difference in the outcome measures, even if it was a weak tendency in favor of the Deprevent™ forte group. There were no reports of adverse effects in any of the groups during the study.

Conclusion: Based on the results from this study we conclude that these nutritive supplements might have a place in the treatment of mood disorders. With its excellent tolerability it might be an attractive supplement to the drug treatments used today.


Effects of nutritional Supplements designed to promote lean tissue accretion on body composition and strength performance. Investigator: Dr. Kjell T÷rnblom, University of Denver, Colorado Participants: Originally 39 volunteers (mixed gender) of which 26 healthy volunteers completed the study. Of these 7 were advanced bodybuilders and 19 actively training at a local gym. Dose: 5 g of unprocessed material corresponding to a daily dose of 2.8 g of YTE™ Design: 17 participants took a combination of YTE + creatine as “active” and 9 took creatine as placebo. Single blind placebo-controlled study over 6 weeks. The difference in change between the two groups is regarded as due to YTE. Parameters: Measurement of muscle mass, strength. Results: Significant improvement in training motivation along with significant change in strength and physical change.

Effects of Protein Supplements on the natural Production of Hormones subsequent to hard Training. 1996/97 Investigator: Bj°dne Eskeland PhD in cooperation with researchers at the Norwegian Academy of Sports. Oslo, Norway. Participants: 9 advanced (male) bodybuilders of 20 – 30 years of age. Dose: Single dose: 200 g of unprocessed powder corresponding to 111 g of YTE™

Design: Single dose double-blind cross-over study with 7 days wash-out period between in order to test the immediate effects of the active substance on hormone production. Parameters: Laboratory tests of testosterone, insulin, cortisol and growth hormone in blood samples

 Participants receiving active substance had a significant reduction of cortisol compared to placebo as well as increased cellular uptake of testosterone and higher insulin levels.


”A randomized placebo-controlled study of”Libido” (YTE) on sexual lust in middle-aged, healthy men” 1992 Investigator: Erling Thom PhD. Oslo, Norway Participants: n= 16 healthy male volunteers between 47 and 60 years (average 52.5) with reduced sexual lust. Average weight 84 kg, height 181 cm, BMI 25.6 Dose: 2 x 3 g of unprocessed material. Corresponds to a daily dose of 3.35 g of YTE™ Design: Group A (n=8) obtained active for 3 weeks, and subsequently placebo for 3 weeks. Group B (n=8) obtained placebo for 3 weeks, and subsequently active for 3 weeks. Parameters: Visual analogue score of 10 cm every week at end of week self-assessment of improvement in sexual lust.

Results: Participants had a significantly higher score on VAS scale at the end of 2nd and 3rd week during Active period vs Placebo period. Comments: Study reported as study 1 in published article (4) 6. “A randomized placebo-controlled study of “Libido” (YTE) on sexual desire in healthy middle-aged men” 1993 Investigators: Dr. KO Svendsen, Dr. Einar Christiansen. Statistics: Erling Thom PhD. Oslo, Norway Participants: n=31 healthy male volunteers between 38 and 65 years (average 50.9) Dose: 2 x 3 g of unprocessed material. Corresponds to a daily dose of 3.35 g of YTE™ Design: Two groups receiving alternating active-placebo or placebo active for 6 periods of 2 weeks (3x2 weeks of active and 3x2 weeks of placebo = 12 weeks) Parameters: Visual analogue score self-assessment at end of every week of improvement of sexual lust. Lab tests of testosterone levels in n=11.

Results: There is a tendency of higher scores in active periods than in placebo periods, but the difference is not significant. 40 – 50 % of the study subjects have no effect. Testosterone levels increased by on average 25 % during the study period, but were well within normal testosterone levels in a healthy population. Comments: Study reported as study 2 in published article (4)

“The Swedish Study”

Investigator: Bj°dne Eskeland PhD. Statistics: Erling Thom PhD. Participants: n=31 male volunteers. No data on age available. Dose: 2x3 g of unprocessed material. Corresponds to a daily dose of 3.5 g of YTE™. Design: This was an open, uncontrolled marketing study in healthy volunteers recruited through ads throughout Sweden. The study was performed without medical supervision. All participants took active substance over 3 weeks. Parameters: 5 point scale of increase in sexual desire -self assessment.

Results: 54.9 % reported definite and very pronounced increase, while 16.1% reported no increase. Comments: Study reported as Swedish study in published article.

Sexual Desire in Men: Effects of Oral Ingestion of a Product Derived from Fertilized Eggs. Authors: B Eskeland, E Thom, KOB Svendsen. Published in the J. of International Med. Research This is an article summarizing the 3 studies referred to above. 9. The Effect of “Libido” (YTE) on decreased sexual Desire associated with Anti-Depressant Medication. 1996/97 Investigator: Dr. Kjell T÷rnblom, University of Denver, Colorado Participants: 11 persons taking anti-depressant medication and having experienced reduced sexual lust in connection with this. 8 persons -5 male and 3 female – completed the study. Age of male participants are 29 – 67 years, females 26 – 39 years. Dose: 2 x 6 tablets of 420 mg unprocessed material (5 g) corresponding to a daily dose of 2.8 g of YTE™. Design: Single blind, placebo-controlled study over 6 weeks. Initially, 3 weeks of active -followed by 3 weeks of placebo. Parameters: a. Derogatis Affects Balance Score (DABS) self assessment at start-up, after 3 weeks and after 6 weeks. b. 9-point Likert scale assessing sexual lust and behavior at same times + after 2 and 5 weeks.

Results: Statistically significant improvements in Intensity of sexual desire, Frequency of sexual desire, energy, and confidence and self esteem.

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